2026
Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis. Molecular Neurodegeneration Advances. Caroline Ackley, Zoe Liau, Shruti Arya, Tara Antee, Emily Cheang, Giselle M Knudsen, Courtney Lane-Donovan, Paul J Sampognaro, Aimee W Kao.
Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion. Journal of Neurochemistry. Molly Hodul, Courtney Lane-Donovan, Emily S Cheang, Vienna Gao, Paul J Sampognaro, Edwina A Mambou, Zoe Yang, Aimee W Kao.
2025
The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases. Progress in Neurobiology. Courtney Lane-Donovan, Mercedes Paredes, Aimee W Kao.
Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease. Neurology Clinical Practice. Nicholas U Schwartz, Connor D Dietz, Igor Prufer Araújo, Javier E Villanueva-Meyer, Winston Chiong, Courtney Lane-Donovan, Lawren Vandevrede, Peter A Ljubenkov, Yingbing Wang, David N Soleimani-Meigooni, Renaud La Joie, Julio C Rojas.
Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases. Alzheimer’s Dementia. Courtney Lane-Donovan, Andrew W Smith, Rowan Saloner, Bruce L Miller, Kaitlin B Casaletto, Aimee W Kao.
2024
Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias. Neurology. Breton M Asken, Jeremy A Tanner, Lawren Vandevrede, Alexandra Apple, Marianne Chapleau, Leslie S Gaynor, Courtney Lane-Donovan, Steven Lenio, Golnaz Yadollahikhales, Shannon Lee, Eva Gontrum, Marguerite Knudtson, Leonardo Iaccarino, Renaud La Joie, Yann Cobigo, Adam M Staffaroni, Kaitlin B Casaletto, Raquel C Gardner, Lea T Grinberg, Maria Luisa Gorno-Tempini, Howard J Rosen, William W Seeley, Bruce L Miller, Joel Kramer, Gil D Rabinovici.
Disentangling Tau: One Protein, Many Therapeutic Approaches. Neurotherapeutics. Courtney Lane-Donovan, Adam Boxer.
2023 and prior
Tau Pathology in Neurodegenerative Disease: Disease Mechanisms and Pathology. (2023). Journal of Clinical Investigation. Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxer.
Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient with AIDS; Case Report and Review of the Literature. (2021). Open Forum Infectious Disease. Courtney Lane-Donovan, Emma Bainbridge, John Szumowski, Andrew D Kerkhoff, Michael J Peluso.
Reelin Regulates Neuronal Excitability through StriatalEnriched Protein Tyrosine Phosphatase (STEP 61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner. (2021). Journal of Neuroscience. Murat S Durakoglugil, Catherine R Wasser, Connie H Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz.
Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease. (2018). Elife. Xunde Xian, Theresa Pohlkamp, Murat S Durakoglugil, Connie H Wong, Jürgen K Beck, Courtney Lane-Donovan, Florian Plattner, Joachim Herz.
Building a better blood-brain barrier. (2017). Elife. Courtney Lane-Donovan and Joachim Herz.
NGP 555, a gammasecretase modulator, lowers the amyloid biomarker, Abeta42, in cerebrospinal fluid while preventing Alzheimer’s disease cognitive decline in rodents. (2017). Alzheimer’s Dementia. Maria Z Kounnas, Courtney Lane-Donovan, Dan W Nowakowski, Joachim Herz, William T Comer.
The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease. (2017). Journal of Lipid Research. Courtney Lane-Donovan and Joachim Herz.
ApoE, ApoE receptors, and the synapse in Alzheimer’s disease. (2017). Trends Endocrinology Metabolism. Courtney Lane-Donovan and Joachim Herz.
Genetic Restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice. (2016). Journal of Neuroscience. Courtney Lane-Donovan, Wen Mai Wong, Murat S Durakoglugil, Catherine R Wasser, Shan Jiang, Xunde Xian, Joachim Herz.
Physiologic Reelin does not play a strong role in protection against acute stroke. (2016). Journal of Cerebral Blood Flow and Metabolism. Courtney Lane-Donovan, Charisma Desai, Theresa Pohlkamp, Erik J Plautz, Joachim Herz, Ann M Stowe.
High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice. (2016). PloS One. Courtney Lane-Donovan and Joachim Herz.
Reelin protects against amyloid beta toxicity in vivo. (2016). Science Signaling. Courtney Lane-Donovan, Gary T Philips, Catherine R Wasser, Murat S Durakoglugil, Irene Masiulis, Ajeet Upadhaya, Theresa Pohlkamp, Cagil Coskun, Tiina Kotti, Laura Steller, Robert E Hammer, Michael Frotscher, Hans H Bock, Joachim Herz.
Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning. (2014). Science Signaling. Catherine R Wasser, Irene Masiulis, Murat S Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Uwe Beffert, Anandita Agarwala, Robert E Hammer, Joachim Herz
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity. (2015). PloS One. Theresa Pohlkamp, Murat Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Eric B Johnson, Robert E Hammer, Joachim Herz
More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. (2014). Neuron. Courtney Lane-Donovan, Gary T Philips, Joachim Herz
Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development. (2014). JAMA Neurology. Courtney Lane-Donovan and Joachim Herz.