Courtney Lane-Donovan, MD, PhD

Assistant Professor - Principal Investigator

M_Neurology

Courtney Lane-Donovan, MD, PhD, is a physician-scientist dedicated to improving the understanding and treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and frontotemporal dementia. As an assistant professor in the Edward and Pearl Fein Memory and Aging Center within the Department of Neurology at UCSF and a Weill Neurohubexternal site (opens in a new window) Investigator, she combines her clinical care for patients with cognitive impairment and dementia with cutting-edge research focused on the biology of aging brain cells. In her spare time, Courtney loves to spend time with her husband and two daughters, run in Golden Gate Park, and explore the bay area. As

Publications

Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis.

Molecular neurodegeneration advances

Ackley C, Liau Z, Arya S, Antee T, Cheang E, Knudsen GM, Lane-Donovan C, Sampognaro PJ, Kao AW

Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion.

Journal of neurochemistry

Hodul M, Lane-Donovan C, Cheang ES, Gao V, Sampognaro PJ, Mambou EA, Yang Z, Kao AW

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases.

Progress in neurobiology

Lane-Donovan C, Paredes M, Kao AW

Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease.

Neurology. Clinical practice

Schwartz NU, Dietz CD, Prufer Araújo I, Villanueva-Meyer JE, Chiong W, Lane-Donovan C, Vandevrede L, Ljubenkov PA, Wang Y, Soleimani-Meigooni DN, La Joie R, Rojas JC

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Lane-Donovan C, Smith AW, Saloner R, Miller BL, Casaletto KB, Kao AW

Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.

Neurology

Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD

Disentangling tau: One protein, many therapeutic approaches.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Lane-Donovan C, Boxer AL

Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.

The Journal of clinical investigation

Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL

Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature.

Open forum infectious diseases

Lane-Donovan C, Bainbridge E, Szumowski J, Kerkhoff AD, Peluso MJ

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.

eLife

Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J

Building a better blood-brain barrier.

eLife

Lane-Donovan C, Herz J

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

Journal of lipid research

Lane-Donovan C, Herz J

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

Trends in endocrinology and metabolism: TEM

Lane-Donovan C, Herz J

NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.

Alzheimer's & dementia (New York, N. Y.)

Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT

Courtney Lane-Donovan, MD, PhD

Publications

Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis.

Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion.

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases.

Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease.

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.

Disentangling tau: One protein, many therapeutic approaches.

Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.

Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature.

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.

Building a better blood-brain barrier.

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.

Physiologic Reelin does not play a strong role in protection against acute stroke.

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.

Reelin protects against amyloid β toxicity in vivo.

Science Signaling
Podcast: 7 July 2015.

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.

Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development.

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.

Intermittent practice facilitates stable motor memories.